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http://hdl.handle.net/123456789/1013
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DC Field | Value | Language |
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dc.contributor.author | Tailor, Prafullakumar | - |
dc.contributor.author | Kumari, Puja | - |
dc.contributor.author | Saha, Irene | - |
dc.contributor.author | Narayanan, Athira | - |
dc.contributor.author | Narayanan, Sathish | - |
dc.contributor.author | Takaoka, Akinori | - |
dc.contributor.author | Kumar, Nachimuthu Senthil | - |
dc.contributor.author | Kumar, Himanshu | - |
dc.date.accessioned | 2018-05-23T07:30:37Z | - |
dc.date.available | 2018-05-23T07:30:37Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/1013 | - |
dc.description.abstract | Cancer is a multifactorial disease and virus-mediated carcinogenesis is one of the crucial factors, which is poorly understood. Human cytomegalovirus (HCMV) is a herpesvirus and its components have been evidenced to be associated with cancer of different tissue origin. However, its role in cancer remains unknown. Here, we identified a conserved herpesviral tegument protein known as pUL48 of HCMV, encoding deubiquitinase enzyme, as having a key role in carcinogenesis. We show using deubiquitinase sufficient- and deficient-HCMV that HCMV deubiquitinase is a key in inducing enhanced cellular metabolic activity through upregulation of several anti-apoptotic genes and downregulation of several pro-apoptotic genes expression. Furthermore, HCMV deubiquitinase acquires pro-tumor functions by inhibiting PRR-mediated type I interferon via deubiquitination of TRAF6, TRAF3, IRAK1, IRF7 and STING. Taken together, our results suggest that HCMV infection may promote oncogenesis by inhibiting innate immunity of the host. | en_US |
dc.publisher | Springer Nature | en_US |
dc.title | Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways | en_US |
dc.journal | Cell Death and Disease | en_US |
dc.volumeno | 8 | en_US |
dc.issueno | 10 | en_US |
dc.pages | e3078 | en_US |
Appears in Collections: | Innate Immunity, Publications |
Files in This Item:
File | Description | Size | Format | |
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12 cddis2017461.pdf | 1.9 MB | Adobe PDF | View/Open Request a copy |
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