Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1078
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dc.contributor.authorPanda, Amulya Kumar-
dc.contributor.authorSaneja, Ankit-
dc.contributor.authorSrichandan, Sudeepa-
dc.contributor.authorSinghvi, Priyank-
dc.date.accessioned2020-07-24T06:14:41Z-
dc.date.available2020-07-24T06:14:41Z-
dc.date.issued2020-05-
dc.identifier.urihttp://hdl.handle.net/123456789/1078-
dc.description.abstractRecombinant proteins expressed as bacterial inclusion bodies (IBs) are now receiving tremendous attention for many diverse applications in the areas of industrial and medical biotechnology. Understanding the structure-function relationship of protein in IBs has recently created new possibilities in developing innovative isolation, solubilization, refolding, and purification processes for high-throughput recovery of bioactive protein from bacterial IBs. This opinion article describes the advantages, disadvantages, and major challenges presently associated with each of the processing steps. Finally, we conclude with the possible solutions for each operational step and the future direction of the basic and translational research to achieve maximum benefit from IB aggregates.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.subjectbacterial inclusion bodies; combinatorial approach; mild solubilization agents; protein aggregates; protein purification; protein refolding.en_US
dc.titleBacterial Inclusion Bodies: A Treasure Trove of Bioactive Proteinsen_US
dc.journalTrends Biotechnolen_US
dc.volumeno38en_US
dc.issueno5en_US
dc.pages474-486en_US
Appears in Collections:Product Development Cell Unit- II, Publications

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