Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1193
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tailor, Prafullakumar | - |
dc.contributor.author | Saha, Irene | - |
dc.contributor.author | Jaiswal, Hemant | - |
dc.contributor.author | Mishra, Richa | - |
dc.contributor.author | Nel, Hendrik J | - |
dc.contributor.author | Schreuder, Jaring | - |
dc.contributor.author | Kaushik, Monika | - |
dc.contributor.author | Chauhan, Kuldeep Singh | - |
dc.contributor.author | Rawat, Bhupendra Singh | - |
dc.contributor.author | Thomas, Ranjeny | - |
dc.contributor.author | Naik, Shalin | - |
dc.contributor.author | Kumar, Himanshu | - |
dc.date.accessioned | 2021-03-22T09:41:02Z | - |
dc.date.available | 2021-03-22T09:41:02Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/1193 | - |
dc.description.abstract | Type I Interferon (IFN) signaling plays a critical role in dendritic cell (DC) development and functions. Inhibition of hyper type I IFN signaling promotes cDC2 subtype development. Relb is essential to development of cDC2 subtype and here we analyzed its effect on type I IFN signaling in DCs. We show that Relb suppresses the homeostatic type I IFN signaling in cDC2 cultures. TLR stimulation of FL-DCs led to RelB induction coinciding with fall in IFN signatures; conforming with the observation Relb expression reduced TLR stimulated IFN induction along with decrease in ISGs. Towards understanding mechanism, we show that effects of RelB are mediated by increased levels of IκBα. We demonstrate that RelB dampened antiviral responses by lowering ISG levels and the defect in cDC2 development in RelB null mice can be rescued in Ifnar1-/- background. Overall, we propose a novel role of RelB as a negative regulator of the type I IFN signaling pathway; fine tuning development of cDC2 subtype. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.subject | Dendritic cell differentiation; Interferon stimulated genes (ISGs); NF-κB signaling; RelB; Type I Interferon (IFN) | en_US |
dc.title | RelB suppresses type I Interferon signaling in dendritic cells | en_US |
dc.type | Article | en_US |
dc.journal | Cell Immunol | en_US |
dc.volumeno | 349 | en_US |
dc.pages | 104043 | en_US |
Appears in Collections: | Innate Immunity, Publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0008874919303995-main.pdf | 2.58 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.