Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1285
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dc.contributor.authorMukhopadhyay, Arnab-
dc.contributor.authorSengupta, Sagar-
dc.contributor.authorDasgupta, Ujjaini-
dc.contributor.authorBajaj, Avinash-
dc.contributor.authorSreekanth, Vedagopuram-
dc.contributor.authorKar, Animesh-
dc.contributor.authorKumar, Sandeep-
dc.contributor.authorPal, Sanjay-
dc.contributor.authorYadav, Poonam-
dc.contributor.authorSharma, Yamini-
dc.contributor.authorKomalla, Varsha-
dc.contributor.authorSharma, Harsh-
dc.contributor.authorShyam, Radhey-
dc.contributor.authorSharma, Ravi Datta-
dc.date.accessioned2022-02-10T05:42:19Z-
dc.date.available2022-02-10T05:42:19Z-
dc.date.issued2021-03-
dc.identifier.urihttp://hdl.handle.net/123456789/1285-
dc.description.abstractIn this study, we describe the engineering of sub-100 nm nanomicelles (DTX-PC NMs) derived from phosphocholine derivative of docetaxel (DTX)-conjugated lithocholic acid (DTX-PC) and poly(ethylene glycol)-tethered lithocholic acid. Administration of DTX-PC NMs decelerate tumor progression and increase the mice survivability compared to Taxotere (DTX-TS), the FDA-approved formulation of DTX. Unlike DTX-TS, DTX-PC NMs do not cause any systemic toxicity and slow the decay rate of plasma DTX concentration in rodents and non-rodent species including non-human primates. We further demonstrate that DTX-PC NMs target demethylation of CpG islands of Sparcl1 (a tumor suppressor gene) by suppressing DNA methyltransferase activity and increase the expression of Sparcl1 that leads to tumor regression. Therefore, this unique system has the potential to improve the quality of life in cancer patients and can be translated as a next-generation chemotherapeutic.en_US
dc.language.isoenen_US
dc.publisherWiley-VCH GmbHen_US
dc.subjectCancer therapy; docetaxel; epigenetic changes; nanomicelles; toxicityen_US
dc.titleBile Acid Tethered Docetaxel-Based Nanomicelles Mitigate Tumor Progression through Epigenetic Changesen_US
dc.typeArticleen_US
dc.journalAngew Chem Int Ed Englen_US
dc.volumeno60en_US
dc.issueno10en_US
dc.pages5394-5399en_US
Appears in Collections:Molecular Aging, Publications

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