Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1406
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBanerjea, Akhil C-
dc.contributor.authorRonsard, Larance-
dc.contributor.authorSood, Vikas-
dc.contributor.authorYousif, Ashraf S-
dc.contributor.authorRamesh, Janani-
dc.contributor.authorShankar, Vijay-
dc.contributor.authorDas, Jishnu-
dc.contributor.authorSumi, N-
dc.contributor.authorRai, Tripti-
dc.contributor.authorMohankumar, Kumaravel-
dc.contributor.authorSridharan, Subhashree-
dc.contributor.authorDorschel, Arianna-
dc.contributor.authorRamachandran, Vishnampettai G-
dc.date.accessioned2022-08-18T11:17:25Z-
dc.date.available2022-08-18T11:17:25Z-
dc.date.issued2019-05-
dc.identifier.urihttp://hdl.handle.net/123456789/1406-
dc.description.abstractC-C chemokine receptor type 5 (CCR5) serves as a co-receptor for Human immunodeficiency virus (HIV), enabling the virus to enter human CD4 T cells and macrophages. In the absence of CCR5, HIV strains that require CCR5 (R5 or M-tropic HIV) fail to successfully initiate infection. Various natural mutations of the CCR5 gene have been reported to interfere with the HIV-CCR5 interaction, which influences the rate of AIDS progression. Genetic characterization of the CCR5 gene in individuals from the National Capital Regions (NCRs) of India revealed several natural point mutations in HIV seropositive/negative individuals. Furthermore, we identified novel frame-shifts mutations in the CCR5 gene in HIV seronegative individuals, as well as the well reported CCR5Δ32 mutation. Additionally, we observed a number of mutations present only in HIV seropositive individuals. This is the first report to describe the genetic variations of CCR5 in individuals from the NCRs of India and demonstrates the utility of investigating understudied populations to identify novel CCR5 polymorphisms.en_US
dc.language.isoenen_US
dc.publisherSpringer Nature Limiteden_US
dc.titleGenetic Polymorphisms in the Open Reading Frame of the CCR5 gene From HIV-1 Seronegative and Seropositive Individuals From National Capital Regions of Indiaen_US
dc.typeArticleen_US
dc.journalSci Repen_US
dc.volumeno9en_US
dc.issueno1en_US
dc.pages7594en_US
Appears in Collections:Virology- II, Publications

Files in This Item:
File Description SizeFormat 
s41598-019-44136-z.pdf1.02 MBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.