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http://hdl.handle.net/123456789/1408| Title: | s8ORF2 protein of infectious salmon anaemia virus is a RNA-silencing suppressor and interacts with Salmon salar Mov10 (SsMov10) of the host RNAi machinery |
| Authors: | Banerjea, Akhil C Mukherjee, Sunil K Zaidi, Rana Rimstad, Espen Lal, Sunil K Thukral, Vandana Varshney, Bhavna Ramly, Rimatulhana B Ponia, Sanket S Mishra, Sumona Karjee Olsen, Christel M |
| Keywords: | Infectious Salmon Anaemia Virus; Salmon salar Mov10; Segment 8 Open Reading Frame 2; SsMov10; Viral suppressor of RNA silencing |
| Issue Date: | Apr-2018 |
| Publisher: | Springer Nature Switzerland AG |
| Abstract: | The infectious salmon anaemia virus (ISAV) is a piscine virus, a member of Orthomyxoviridae family. It encodes at least 10 proteins from eight negative-strand RNA segments. Since ISAV belongs to the same virus family as Influenza A virus, with similarities in protein functions, they may hence be characterised by analogy. Like NS1 protein of Influenza A virus, s8ORF2 of ISAV is implicated in interferon antagonism and RNA-binding functions. In this study, we investigated the role of s8ORF2 in RNAi suppression in a well-established Agrobacterium transient suppression assay in stably silenced transgenic Nicotiana xanthi. In addition, s8ORF2 was identified as a novel interactor with SsMov10, a key molecule responsible for RISC assembly and maturation in the RNAi pathway. This study thus sheds light on a novel route undertaken by viral proteins in promoting viral growth, using the host RNAi machinery. |
| URI: | http://hdl.handle.net/123456789/1408 |
| Appears in Collections: | Virology- II, Publications |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Thukral2018_Article_S8ORF2.pdf | 2.7 MB | Adobe PDF | View/Open Request a copy |
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