Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/335
Title: T cell ageing: effects of age on development, survival & function
Authors: Bal, Vineeta
Salam, Nasir
Rane, Sanket
Das, Rituparna
Faulkner, Matthew
Gund, Rupali
Kandpal, Usha
Lewis, Virginia
Mattoo, Hamid
Prabhu, Savit
Ranganathan, Vidya
Durdik, Jeannine
George, Anna
Rath, Satyajit
Issue Date: Nov-2013
Publisher: Indian Journal of Medical Research
Abstract: Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.
URI: http://hdl.handle.net/123456789/335
Appears in Collections:Immuno Biology-II, Publications

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