Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/335
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dc.contributor.authorBal, Vineeta-
dc.date.accessioned2014-12-11T08:42:22Z-
dc.date.available2014-12-11T08:42:22Z-
dc.date.issued2013-11-
dc.identifier.urihttp://hdl.handle.net/123456789/335-
dc.description.abstractAge associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.en_US
dc.publisherIndian Journal of Medical Researchen_US
dc.titleT cell ageing: effects of age on development, survival & functionen_US
dc.contributor.coauthorSalam, Nasir-
dc.contributor.coauthorRane, Sanket-
dc.contributor.coauthorDas, Rituparna-
dc.contributor.coauthorFaulkner, Matthew-
dc.contributor.coauthorGund, Rupali-
dc.contributor.coauthorKandpal, Usha-
dc.contributor.coauthorLewis, Virginia-
dc.contributor.coauthorMattoo, Hamid-
dc.contributor.coauthorPrabhu, Savit-
dc.contributor.coauthorRanganathan, Vidya-
dc.contributor.coauthorDurdik, Jeannine-
dc.contributor.coauthorGeorge, Anna-
dc.contributor.coauthorRath, Satyajit-
dc.keywordAdaptive immunity, Ageing, Haematopoietic stem cells, Innate immunity, TCR repertoire, T cells, Thymic involution, Transcription factorsen_US
dc.journalIndian Journal of Medical Researchen_US
dc.volumeno138en_US
dc.issueno5en_US
dc.pages595-608en_US
Appears in Collections:Immuno Biology-II, Publications

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