Salmonella Acquires Lysosome-associated Membrane Protein 1 (LAMP1) on Phagosomes from Golgi via SipC Protein-mediated Recruitment of Host Syntaxin6*

Abstract

Background: Intracellular pathogens avoid lysosomal targeting but recruit lysosome-associated membrane protein 1 (LAMP1), the mechanism of which remains unclear. Results: SipC binds with Syntaxin6 and acquires LAMP1 on the phagosome by fusing with Golgi-derived vesicles. Conclusion: This is a novel mechanism by which Salmonella acquires LAMP1 from Golgi. Significance: This is the first demonstration showing how an intracellular pathogen like Salmonella recruits LAMP1 without fusing with lysosomes