Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/476
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBukovsky, Antonin-
dc.date.accessioned2015-02-12T09:54:49Z-
dc.date.available2015-02-12T09:54:49Z-
dc.date.issued2008-03-
dc.identifier.urihttp://hdl.handle.net/123456789/476-
dc.description.abstractThe concept of neo-oogenesis and follicular renewal during adulthood in mammalian females, including humans, is a novel concept with major significance for ovarian physiology and mammalian reproductive biology. Previous observations from our laboratory demonstrated that mesenchymal cells in the tunica albuginea are bipotent progenitors for both granulosa and germ cells in adult human ovaries. In the present studies, we demonstrate that the antibodies against meiotic entry synaptonemal complex protein 3 (SCP3)--a marker or meiosis, showed reactivity with segments of tunica albuginea and ovarian surface epithelium, and in oocytes of some primordial follicles in functional human and monkey ovaries. These observations suggest that SCP3 is expressed in adult human and monkey ovaries. Preparation for meiotic activity may have already occurred at the level of tunica albuginea stem cells, and meiotic prophase activity may continue and terminate in oocytes of newly formed primordial follicles.en_US
dc.publisherLandes Bioscienceen_US
dc.titleMammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovariesen_US
dc.contributor.coauthorCaudle, Michael R.-
dc.contributor.coauthorGupta, Satish Kumar-
dc.contributor.coauthorSvetlikova, Marta-
dc.contributor.coauthorSelleck-White, Rachel-
dc.contributor.coauthorAyala, Alena M.-
dc.contributor.coauthorDominguez, Roberto-
dc.keywordNeo-oogenesis, Meiosis, SCP3, Adult ovary, Human, Non-human primates, Ovaryen_US
dc.journalCell Cycleen_US
dc.volumeno7en_US
dc.issueno5en_US
dc.pages683-686en_US
Appears in Collections:Reproductive Cell Biology, Publications

Files in This Item:
File Description SizeFormat 
Cell Cycle 75 683-686.pdfMain article (access limited)370.79 kBAdobe PDFView/Open    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.