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http://hdl.handle.net/123456789/535
Title: | Sperm associated antigen 9 expression and humoral response in chronic myeloid leukemia |
Authors: | Suri, Anil Kanojiaa, Deepika Garga, Manoj Sainia, Shikha Agarwala, Sumit Kumar, Rajive |
Issue Date: | Jul-2010 |
Publisher: | Elsevier Ltd. |
Abstract: | Early diagnosis and cure for patients with chronic myeloid leukemia (CML) exhibit significant clinical challenges because of the disease progression from chronic phase (CP) into a rapidly fatal blast crisis. Our earlier studies suggested an association of sperm associated antigen 9 (SPAG9) with various human malignancies. The present investigation revealed that SPAG9 mRNA and protein are expressed in CML patients (88%), in K562 and KCL-22 cells. Further, SPAG9 protein expression was also detected on cell surface suggesting that this molecule may be a suitable target for immunotherapy. Interestingly, 90% CML-CP patients showed humoral response against SPAG9, suggesting its important role in early diagnostic of CML-CP. Further investigation is warranted in establishing the potential of SPAG9 as a biomarker and immunotherapeutic target for early treatment of CML-CP patients. |
URI: | http://hdl.handle.net/123456789/535 |
Appears in Collections: | Genes and Proteins, Publications |
Files in This Item:
File | Description | Size | Format | |
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2010 Leukemia_Research.pdf | Main article (access limited) | 1.96 MB | Adobe PDF | View/Open Request a copy |
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