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http://hdl.handle.net/123456789/589
Title: | Ribotoxin restrictocin manifests anti-HIV-1 activity through itsspecific ribonuclease activity |
Authors: | Batra, Janendra K Yadava, Santosh K |
Issue Date: | May-2015 |
Publisher: | Elsevier B.V. |
Abstract: | Restrictocin, a highly specific ribonuclease produced by Aspergillus restrictus, cleaves a single phosphodiester bond in a universally conserved stem and loop structure termed sarcin/ricin loop within the large ribosomal RNA of all organisms. In the current study, we demonstrate restrictocin to manifest anti-HIV-1 activity in two model cell systems. Using two mutants of restrictocin, we further show that the anti-HIV-1 activity of restrictocin is due to its specific ribonucleolytic activity. The study suggests that restrictocin is able to recognize region(s) within HIV-1 genome as its target. Restrictocin appears to have potential as a therapeutic antiviral agent against HIV-1. |
URI: | http://hdl.handle.net/123456789/589 |
Appears in Collections: | Immunochemistry, Publications |
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1-s2.0-S0141813015000963-main.pdf | Research article (access limited) | 519.89 kB | Adobe PDF | View/Open Request a copy |
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