Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/589
Title: Ribotoxin restrictocin manifests anti-HIV-1 activity through itsspecific ribonuclease activity
Authors: Batra, Janendra K
Yadava, Santosh K
Issue Date: May-2015
Publisher: Elsevier B.V.
Abstract: Restrictocin, a highly specific ribonuclease produced by Aspergillus restrictus, cleaves a single phosphodiester bond in a universally conserved stem and loop structure termed sarcin/ricin loop within the large ribosomal RNA of all organisms. In the current study, we demonstrate restrictocin to manifest anti-HIV-1 activity in two model cell systems. Using two mutants of restrictocin, we further show that the anti-HIV-1 activity of restrictocin is due to its specific ribonucleolytic activity. The study suggests that restrictocin is able to recognize region(s) within HIV-1 genome as its target. Restrictocin appears to have potential as a therapeutic antiviral agent against HIV-1.
URI: http://hdl.handle.net/123456789/589
Appears in Collections:Immunochemistry, Publications

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