Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/600
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dc.contributor.authorRath, Satyajit-
dc.date.accessioned2015-06-19T08:40:24Z-
dc.date.available2015-06-19T08:40:24Z-
dc.date.issued2010-10-
dc.identifier.urihttp://hdl.handle.net/123456789/600-
dc.description.abstractGerm-line retroviral insertions in vertebrate genomes are implicated in the modulation of host immune responses. We demonstrate that CBA/J mice, which carry the proviral integrants mammary tumor virus locus 6 (Mtv6) and mammary tumor virus locus 7 (Mtv7), are less resistant to infection with the protozoan pathogen Leishmania major compared with closely related but Mtv6-negative and Mtv7-negative CBA/CaJ mice. Although both strains generated comparable L. major-specific CD4 T cell frequencies, T cells from CBA/J mice made much less interferon γ (IFN-γ). L. major-infected CBA/CaJ dendritic cells primed L. major-specific and allospecific IFN-γ-producing CD4 T cells better in vivo and in vitro, respectively, than CBA/J dendritic cells did. L. major susceptibility appeared to be associated with Mtv7, and v-Sag-7 superantigen expression and L. major infection together reduced the ability of an antigen-presenting cell line to prime alloresponder CD4 T cells for IFN-γ commitment. These data show that an endogenous superantigen can interact with L. major infection to alter antigen-presenting cell properties and modulate T cell cytokine commitment, with implications for human susceptibility to infectious diseases.en_US
dc.publisherInfectious Diseases Society of Americaen_US
dc.titleA superantigen interacts with leishmanial infection in antigen-presenting cells to regulate cytokine commitment of responding CD4 T cellsen_US
dc.contributor.coauthorVaranasi, Vineeth-
dc.contributor.coauthorMattoo, Hamid-
dc.contributor.coauthorTupperwar, Nitin C-
dc.contributor.coauthorThyagarajan, Krishnamurthy-
dc.contributor.coauthorDas, Abhishek-
dc.contributor.coauthorKumar, Ramesh-
dc.contributor.coauthorBal, Vineeta-
dc.contributor.coauthorVaidya, Tushar-
dc.contributor.coauthorGeorge, Anna-
dc.journalJournal of Infectious Diseasesen_US
dc.volumeno202en_US
dc.issueno8en_US
dc.pages1234-1245en_US
Appears in Collections:Immumo Biology- I, Publications

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