Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/638
Title: A role for apoptosis-inducing factor in T cell development
Authors: Rath, Satyajit
Banerjee, Hridesh
Das, Abhishek
Srivastava, Smita
Mattoo, Hamid R
Thyagarajan, Krishnamurthy
Khalsa, Jasneet Kaur
Tanwar, Shalini
Das, Deepika Sharma
Majumdar, Subeer S
George, Anna
Bal, Vineeta
Durdik, Jeannine M
Issue Date: Aug-2012
Publisher: The Rockefeller University Press
Abstract: Apoptosis-inducing factor (Aif) is a mitochondrial flavoprotein that regulates cell metabolism and survival in many tissues. We report that aif-hypomorphic harlequin (Hq) mice show thymic hypocellularity and a cell-autonomous thymocyte developmental block associated with apoptosis at the β-selection stage, independent of T cell receptor β recombination. No abnormalities are observed in the B cell lineage. Transgenes encoding wild-type or DNA-binding-deficient mutant Aif rectify the thymic defect, but a transgene encoding oxidoreductase activity-deficient mutant Aif does not. The Hq thymic block is reversed in vivo by antioxidant treatment, and Hq T but not B lineage cells show enhanced oxidative stress. Thus, Aif, a ubiquitous protein, serves a lineage-specific nonredundant antiapoptotic role in the T cell lineage by regulating reactive oxygen species during thymic β-selection.
URI: http://hdl.handle.net/123456789/638
Appears in Collections:Cellular Endocrinology, Publications

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