Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/831
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dc.contributor.authorGeorge, Anna-
dc.date.accessioned2016-05-09T07:39:46Z-
dc.date.available2016-05-09T07:39:46Z-
dc.date.issued2014-03-
dc.identifier.urihttp://hdl.handle.net/123456789/831-
dc.description.abstractWhile a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed enhanced death in vitro, after transfer into congenic adoptive hosts, and in chimeras made with wild-type and Nos2(-/-) bone marrow. The iNOS-mediated protection involved activation of protein kinase G and modulation of endoplasmic reticulum stress components. Activation of caspases was also diminished. We found that iNOS was required for PCs to respond to some prosurvival mediators associated with bone marrow stromal cells and that at least one mediator, interleukin 6, fed directly into this pathway by inducing iNOS.en_US
dc.publisherNature America, Incen_US
dc.titleInducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cellsen_US
dc.contributor.coauthorSaini, Ankur S-
dc.contributor.coauthorShenoy, Gautam N-
dc.contributor.coauthorRath, Satyajit-
dc.contributor.coauthorBal, Vineeta-
dc.journalNature Immunologyen_US
dc.volumeno15en_US
dc.issueno3en_US
dc.pages275-282en_US
Appears in Collections:Mucosal Immunology, Publications

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