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http://hdl.handle.net/123456789/836
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DC Field | Value | Language |
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dc.contributor.author | George, Anna | - |
dc.contributor.author | Bal, Vineeta | - |
dc.date.accessioned | 2016-05-09T09:31:38Z | - |
dc.date.available | 2016-05-09T09:31:38Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/836 | - |
dc.description.abstract | Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population. | en_US |
dc.publisher | Wolters Kluwer - Medknow | en_US |
dc.title | T cell ageing: Effects of age on development, survival & function | en_US |
dc.contributor.coauthor | Rane, Sanket | - |
dc.contributor.coauthor | Das, Rituparna | - |
dc.contributor.coauthor | Faulkner, Matthew | - |
dc.contributor.coauthor | Gund, Rupali | - |
dc.contributor.coauthor | Kandpal, Usha | - |
dc.contributor.coauthor | Lewis, Virginia | - |
dc.contributor.coauthor | Mattoo, Hamid | - |
dc.contributor.coauthor | Prabhu, Savit | - |
dc.contributor.coauthor | Ranganathan, Vidya | - |
dc.contributor.coauthor | Durdik, Jeannine | - |
dc.contributor.coauthor | Salam, Nasir | - |
dc.contributor.coauthor | Rath, Satyajit | - |
dc.keyword | Adaptive immunity - ageing - haematopoietic stem cells - innate immunity - TCR repertoire - T cells - thymic involution - transcription factors | en_US |
dc.journal | Indian Journal of Medical Research | en_US |
dc.volumeno | 138 | en_US |
dc.issueno | 5 | en_US |
dc.pages | 595-608 | en_US |
Appears in Collections: | Mucosal Immunology, Publications |
Files in This Item:
File | Description | Size | Format | |
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IndianJMedRes1385595-1634118_043221.pdf | Research article | 1.17 MB | Adobe PDF | View/Open Request a copy |
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