Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/968
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dc.contributor.authorMohanty, Debasisa-
dc.contributor.authorKhater, Shradha-
dc.contributor.authorAnand, Swadha-
dc.date.accessioned2017-08-24T07:22:22Z-
dc.date.available2017-08-24T07:22:22Z-
dc.date.issued2016-06-
dc.identifier.urihttp://hdl.handle.net/123456789/968-
dc.description.abstractIn silico methods for linking genomic space to chemical space have played a crucial role in genomics driven discovery of new natural products as well as biosynthesis of altered natural products by engineering of biosynthetic pathways. Here we give an overview of available computational tools and then briefly describe a novel computational framework, namely retro-biosynthetic enumeration of biosynthetic reactions, which can add to the repertoire of computational tools available for connecting natural products to their biosynthetic gene clusters. Most of the currently available bioinformatics tools for analysis of secondary metabolite biosynthetic gene clusters utilize the “Genes to Metabolites” approach. In contrast to the “Genes to Metabolites” approach, the “Metabolites to Genes” or retro-biosynthetic approach would involve enumerating the various biochemical transformations or enzymatic reactions which would generate the given chemical moiety starting from a set of precursor molecules and identifying enzymatic domains which can potentially catalyze the enumerated biochemical transformations. In this article, we first give a brief overview of the presently available in silico tools and approaches for analysis of secondary metabolite biosynthetic pathways. We also discuss our preliminary work on development of algorithms for retro-biosynthetic enumeration of biochemical transformations to formulate a novel computational method for identifying genes associated with biosynthesis of a given polyketide or nonribosomal peptide.en_US
dc.publisherElsevier B.V.en_US
dc.titleIn silico methods for linking genes and secondary metabolites: The way forwarden_US
dc.keywordSecondary metabolite Polyketides, Nonribosomal peptides, Genes to metabolites, Metabolites to genes, Genome mining, Retro-biosynthetic enumeration, Biosynthetic gene clusteren_US
dc.journalSynthetic and Systems Biotechnologyen_US
dc.volumeno1en_US
dc.issueno2en_US
dc.pages80-88en_US
Appears in Collections:Bioinformatics Centre, Publications

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